ANXA1 and obesity due to melanocortin 4 receptor deficiency: The prevailing view among many researchers is that adipogenesis contributes to the development of obesity.52,53 However, a counter-argument suggests that additional expansion of adipose tissue could potentially enhance metabolic health in individuals afflicted with obesity.12,54 Our findings align with the majority perspective, demonstrating that the absence of ANXA1 accelerates the transformation of preadipocytes into adipocytes.