PPIs are essential for most biological processes governing life.46 This study has unveiled PDLIM7 and MYCBP2 as novel potential targets in the fight against obesity and uncovered a novel mechanism whereby ANXA1-PDLIM7-MYCBP2-SMAD4 PPIs influences adipogenesis. This evidence concerns the gene SMAD4 and obesity due to melanocortin 4 receptor deficiency.