CpG-SAV-exo could efficiently stimulate DC2.4 cells, promote the release of TNF-α, IL-6, and IL-12p40, and reinforce tumor antigen presentation, which induced a potent Th1-type humoral immune response and remarkable CTL activity, thereby demonstrating a robust anti-tumor effect in B16BL6 melanoma-bearing mice. This evidence concerns the gene IL6 and neoplasm.