CD8A and melanoma: Kim et al. found that gamma-irradiated melanoma cancer cell-derived exosome significantly promoted DC maturation, enhanced the expression of surface molecules, the release of pro-inflammatory cytokines, antigen-presenting capacity, and reduced endocytosis, which resulted in effective activation of T cells, particularly Th1 and IFN-γ-producing CD8+ T cells, ultimately significantly decreasing the tumor growth in melanoma mice [77].