CD274 and neoplasm: Ye et al. developed a novel type of nanoparticles, Golgi apparatus-Pd-l1−/−exosome hybrid membrane coated nanoparticles (GENPs), which were capable of interfering with PD-L1 synthesis and PD-L1-bearing exosome secretion within the Golgi of tumor cells, thus possessing the potential to reverse the immunosuppressive TME [103].