Upon NUP37 depletion in U87 glioma cells, significant decreases were observed in various biological pathways, including cell cycle checkpoints, DNA strand elongation in DNA replication, activation of pre-replication complexes, G1–G1/S phase progression in mitosis, G1–S phase transition, S phase of mitosis, DNA synthesis, and centrosome signal amplification. This evidence concerns the gene NUP37 and glioma.