IL6 and dentin dysplasia: The role of systemic inflammation in the atherosclerotic process and development of CVD in different diseases, including in GI disease, has been reported in both randomized clinical trials24 and epidemiological population-based studies.8,9,25 Chronic low-grade inflammation has been proposed to be involved in the pathogenesis of DD.12,26 Moreover, elevated levels of circulating C-reactive protein and interleukin 6, as markers of chronic inflammation, have been described in DD.27,28 We speculate that these mechanisms may harbour an increased risk of CVD outcomes in individuals with DD.