INS and type 1 diabetes mellitus: Given the apparent essential nature of T cell responses to insulin for the development of T1D (41), as well as the importance of T cells specific for G6Pase 2 in the preclinical NOD mouse model (42, 43, 44), we investigated the binding of peptides derived from these autoantigens to the closely related HLA-B allotypes (B∗39:06, B∗39:01, and B∗38:01).