TGFB1 and Hepatic fibrosis: Particularly regarding S. mansoni infection-triggered hepatic fibrosis within eosinophilic granulomas, de Oliveira and coauthors (2022) revealed that in the absence of eosinophils, reductions in TGF-β and IL-13 levels were accompanied by attenuation of hepatic fibrosis [49], thus indicating a pro-fibrogenic role for eosinophils in the disease.