These findings are in clear contrast with the inverse relationship between S. mansoni infection-related eosinophilia and fibrogenesis observed here, whereby decreasing PGD2-driven eosinophilia (Figs 3 and 4), HQL-79 and CAY-10471 did increase the fibrogenic cytokines as well as hepatic fibrosis (Fig 2). Here, HPGDS is linked to fibrosis.