Although simple extrapolation of PGD2’s role in liver fibrosis based on evidence gathered on different tissues may not be straightforward, it is reasonable to speculate that schistosomiasis-driven fibrosis may be promoted by PGD2, in a similar pro-fibrotic fashion as it is in asthma due to the shared type 2-governed eosinophilic environment. Here, HPGDS is linked to schistosomiasis.