Finally, it is important to note that some PVs have a strong effect on pancreatitis risk and can be considered causative of pancreatitis, such as PRSS1 R122H, while other PVs have lesser effects on pancreatitis risk and should be considered pancreatitis risk genes, such as heterozygous CFTR F508del or SPINK1 N34S [37]. This evidence concerns the gene SPINK1 and pancreatitis.