Variants in other possible pancreatitis-related genes, including CEL, CLDN2, GGT1, MORC4, PRSS3, SBDS, SLC26A9, TRPV6, and UBR1, may provide an explanation for otherwise unexplained AP or CP in some subjects but the significance of many variants have not been fully characterized to date [5]. This evidence concerns the gene CLDN2 and pancreatitis.