Notably, miR-9 and hsa-let-7b-5p are essential to atherosclerosis and coronary artery disease development [61, 78], and miR-486 confers protection against cardiac myocardial apoptosis by targeting PTEN and FoxO1 and activating the AKT/mTOR pathway, holding promise as a therapeutic strategy for myocardial protection [79]. This evidence concerns the gene AKT1 and coronary artery disorder.