Strikingly, while Foz/Foz mice successfully eliminated >50% of hepatic fat deposits by 8 wk of WD to chow switch, Foz::Trem2−/− mice failed to eliminate hepatic steatosis (Fig. 2 B and D) and had higher liver weights compared to Foz/Foz regression mice (SI Appendix, Fig. S2A). This evidence concerns the gene TREM2 and Wilson disease.