The former cluster consisted of neutrophil antimicrobial and granule marker genes (e.g. DEFA3, DEFA4, SERPINB10, CTSG), while in the latter cluster the most significantly upregulated genes in the PMNs from severe COVID-19 subgroup were mainly interferon inducible (e.g. IFI44L, IFI6, GBP3, IRF7). The gene discussed is SERPINB10; the disease is COVID-19.