Based on these findings, we determined that MX1 and RSAD2 levels were significantly higher in the NP of CoV2 + patients with higher viral RNA level at initial stage of infection and the induction of both IFNs and ISGs in the NP of CoV2 + patients may be closely correlated to the good prognosis of COVID-19 treatment. This evidence concerns the gene MX1 and COVID-19.