Elliott et al. indicated that the phosphorylation level of c-Src was strongly elevated in ADPKD epithelial cells, inactivation of c-Src could suppress ADPKD cell proliferation and extracellular matrix-attachment in vitro, as well as reduce cyst formation in ADPKD mice in vivo [31]. Here, SRC is linked to autosomal dominant polycystic kidney disease.