After constructing the component‐target‐pathway network, we identified six key targets of action: CASP1, CASP3, CASP8, FGFR1, MAPK14, and PIK3CG, of which CASP1, CASP3, and CASP8 influence the progression of PF by activating proinflammatory cytokines and initiating apoptotic cascades.15, 16. This evidence concerns the gene PIK3CG and pemphigus foliaceus.