After constructing the component‐target‐pathway network, we identified six key targets of action: CASP1, CASP3, CASP8, FGFR1, MAPK14, and PIK3CG, of which CASP1, CASP3, and CASP8 influence the progression of PF by activating proinflammatory cytokines and initiating apoptotic cascades.15, 16. The gene discussed is CASP3; the disease is pemphigus foliaceus.