Results of in vivo experiments showed that, compared with the CON group, the lung coefficients of mice in the BLM group were significantly higher, the alveolar walls were significantly thickened, a large number of inflammatory cell infiltration appeared in the mesenchyme, and CF deposition was significantly increased, which showed obvious destruction of alveolar structure and inflammatory infiltration, suggesting that a mice model of PF had been successfully induced and established by BLM. This evidence concerns the gene CFTR and pemphigus foliaceus.