In the present study, we found that FA inhibited the expression level of the inflammatory factor IL‐6, and the expression of apoptosis‐related genes FasL, Fas, Bax/Bcl‐2, Cleaved caspase‐3, Cleaved caspase‐3/caspase‐3, suppressed the expression of oxidative stress‐related gene NOX4 in the lung tissues of mice with BLM‐induced PF, elevated the expression of antioxidant‐related genes HO‐1, CAT‐1, and p‐Nrf2/Nrf2 expression, and improved the pathological changes in lung tissues, suggesting that the improvement of PF by FA is related to the regulation of apoptosis and oxidative stress. The gene discussed is FAS; the disease is pemphigus foliaceus.