Our findings suggested that serum CXCL9, CXCL10, and CXCL11 levels were significantly higher in SLE‐LN patients, comparing to SLE patients and HCs, and the ROC analysis of CXCL chemokines can significantly improve sensitivity and specificity for the diagnosis of LN in SLE patients, demonstrating the diagnostic value of serum CXCL9, CXCL10, and CXCL11 in LN and their correlation with the activity level of LN. The gene discussed is CXCL9; the disease is lobular neoplasia.