Similarly, obesity and dyslipidemia can increase senescence markers, such as senescence-associated β-galactosidase activity and p16, p19, p21, and p53 gene expression in many cell types, including cells of adipose tissue, aorta, pancreas, liver, and endothelium (27–32). This evidence concerns the gene CDKN2A and obesity due to melanocortin 4 receptor deficiency.