Furthermore, the restoration of bone mass, bone formation rate, and strength induced by anabolic ligands of the parathyroid hormone 1 receptor teriparatide and abaloparatide (ABL) in T2D mice to control levels was accompanied by a reduction in Sost expression in bone, and ABL also reduced sclerostin levels in the circulation (12). This evidence concerns the gene SOST and type 2 diabetes mellitus.