Here, we have investigated the function of kinesin-1 in DCV movement in C. elegans, using worms expressing GFP-tagged IDA-1 (‘islet cell diabetes autoantigen-1’) protein, which is the C. elegans orthologue of mammalian type-1 diabetes auto-antigen proteins insulinoma associated protein-2 (IA-2; also known as INSM2) and phogrin (IA-2β; also known as PTPRN2) (Cai et al., 2001; Zahn et al., 2001). The gene discussed is INSM2; the disease is type 1 diabetes mellitus.