Similar observations were made by Do et al. (78) and others where SNPs in TG raising alleles e.g., ANGPTL3, APOC2, APOA5, GPIHBP1, LMF1 were found to increase the risk of ASCVD, while conversely, in APOC3 loss of function heterozygosity led to reduction in ASCVD events (79–81). The gene discussed is APOC3; the disease is atherosclerosis.