PCSK9 and atherosclerosis: The Further cardiovascular OUtcomes Research with PCSK9 Inhibition subjects with Elevated Risk (FOURIER) trial evaluated patients with known ASCVD with pre-treatment LDL-C of 2.4 mmol/L (92 mg/dl) that was reduced to 0.7 mmol/L (30 mg/dl) with evolocumab, 9.8% of drug recipients still experienced ASCVD events over median followup period of 2.2 years (14).