Autoantibodies tend to be associated with organ-specific irAEs, such as anti-thyroid antibodies for thyroid irAEs, anti-bullous pemphigoid (BP) 180 immunoglobulin G (IgG) for skin irAEs, anti-G protein subunit alpha L (GNAL) antibodies for pituitary irAEs, and anti-CD74 for lung irAEs.70, 71, 72 A growing number of studies have demonstrated the relevance of fecal microbiology to irAEs, particularly for colitis. The gene discussed is GNAL; the disease is colitis.