As for the ATF3-related pathways, malaria, rheumatoid arthritis, legionellosis, pertussis, NF-kappa B signaling pathway, and TNF signaling pathway were activated, and drug metabolism-cytochrome P450, ascorbate and aldarate metabolism, histidine metabolism, glycine serine and threonine metabolism, arginine biosynthesis and taurine and hypotaurine metabolism were inhibited (Figure 5(f)). Here, TNF is linked to rheumatoid arthritis.