After comprehensive analysis, it was revealed that the signaling pathways associated with JUN expression were mainly glycosaminoglycan biosynthesis (chondroitin sulfate/dermatan sulfate), one carbon pool by folate, pantothenate and CoA biosynthesis, galactose metabolism, leishmaniasis, and B cell receptor signaling pathways; the inhibition pathways were mainly ascorbate and aldarate metabolism, fatty acid degradation, butanoate metabolism, collecting duct acid secretion, renin–angiotensin system, and beta-alanine metabolism (Figure 5(d)). This evidence concerns the gene REN and leishmaniasis.