As for the ATF3-related pathways, malaria, rheumatoid arthritis, legionellosis, pertussis, NF-kappa B signaling pathway, and TNF signaling pathway were activated, and drug metabolism-cytochrome P450, ascorbate and aldarate metabolism, histidine metabolism, glycine serine and threonine metabolism, arginine biosynthesis and taurine and hypotaurine metabolism were inhibited (Figure 5(f)). Here, TNF is linked to legionellosis.