IL1B and rheumatoid arthritis: The main signaling pathways associated with IL1B were identified as rheumatoid arthritis, malaria, glycine serine and threonine metabolism, phenylalanine metabolism, African trypanosomiasis, IL-17 signaling pathway, human immunodeficiency virus 1 infection, chemical carcinogenesis-receptor activation, and pathogenic Escherichia coli infection; the main inhibited pathways included ECM–receptor interaction, selenocompound metabolism, and taurine and hypotaurine metabolism (Figure 5(e)).