The reasons for withholding t-PA included cardiac arrest before t-PA administration (case 2), existing anticoagulant therapy (case 4), refractory hypertension (case 5), elapsed treatment window (case 6), potential need for dual antiplatelet agents therapy prior to PCI (case 10), unknown stroke onset time (case 13 and case 15), and low NIHSS score and no cerebral occlusion (case 18). This evidence concerns the gene PLAT and cardiac arrest.