TNF and psoriasis: An animal experiment studying the improvement of psoriasis symptoms by quercetin supplementation showed that quercetin can significantly reduce the levels of TNF-α, IL-6, and IL-17 induced by imiquimod in mouse serum, simultaneously inhibit NF-κB signaling activation, enhance anti-inflammatory and antioxidant properties, thereby reducing psoriasis severity index (PASI) scores and improving symptoms (Chen et al., 2017).