IFNG and psoriasis: Additionally, multiple studies have shown that alterations in the gut microbiota composition participate in the pathophysiology of psoriasis by activating various immune mediators such as IL-23, IL-17, IL-22, regulating interferon-gamma (IFN-gamma), and inhibiting the production of T regulatory cells (Tregs) (Mann et al., 2020; Kapoor et al., 2022).