In various clinical trials, probiotics have been shown to significantly improve the severity of skin lesions and quality of life in psoriasis patients, and reduce levels of inflammatory markers such as high-sensitivity C-reactive protein(hs-CRP) and IL-6 (Moludi et al., 2021; Moludi et al., 2022; Choy et al., 2023). The gene discussed is IL6; the disease is psoriasis.