This imbalance activates the NF-kB pathway, further activating inflammatory factors, triggering inflammation reactions, compromising barrier integrity, and participating in the pathogenesis of Psoriasis (Zheng et al., 2017; Codoñer et al., 2018; Stoeva et al., 2021; Valentini et al., 2021). Here, NFKB1 is linked to psoriasis.