Despite limited reports on circulating PAMP levels in patients with psoriasis, existing studies have indicated that PAMPs or Damage-Associated Molecular Patterns(DAMPs) in psoriasis patients can be recognized by Pattern Recognition Receptors(PRRs, thereby activating immune responses in keratinocytes or Plasmacytoid Dendritic Cells(pDCs), promoting the release of various pro-inflammatory cytokines including IFNβ, IL1β, IL36, TNF, IL6, IL8, IL25, and CXCL10. Here, TNF is linked to psoriasis.