ORMDL3 and asthma: The contribution of ORMDL3 expression to risk of childhood asthma (Moffatt et al., 2007) is less clear, with transgenic mice showing airway remodelling consistent with asthmatic disease (Miller et al., 2014) and no impact of ORMDL3 expression on asthma responses in allergen tests (Debeuf et al., 2019).