Chieng and Say (2015) demonstrated that overexpression of PrPC in LS 174T cells promotes cell growth and proliferation, while the proliferation of colon cancer cells significantly reduced after siRNA knockdown of PrPC in DLD-1 and SW480 CRC cell lines. Yun et al. (2016) found that HT29 cells treated with fucoidan exhibited decreased cell proliferation, diminished levels of the anti-apoptotic protein Bcl-2, and heightened levels of pro-apoptotic proteins Bax, cleaved caspase-3, and cleaved PARP1. This evidence concerns the gene CASP3 and malignant colon neoplasm.