Previous studies have confirmed a link between PRNP(PrPC) and the occurrence and development of gastric cancer, CRC, lung cancer, and breast cancer, with its expression being linked to drug resistance, proliferation, apoptosis, migration, and invasion of various malignant tumor cells (Gil et al., 2016; Castle and Gill, 2017; Luo et al., 2017; Atkinson et al., 2019; Lin et al., 2020). The gene discussed is PRNP; the disease is cancer.