Conversely, when the PrPC gene was overexpressed, the expression of N-cadherin (p < 0.01, p < 0.001), Vimentin (both p < 0.05) and Snail (p < 0.01, p < 0.001) increased, and E-cadherin decreased (both p < 0.01) in both CRC cell lines. The gene discussed is PRNP; the disease is colorectal carcinoma.