These indirect effects for processing speed remained significant after additionally controlling for APOE ε4 status, hypertension status, smoking history, VO2max, and vitamin B12 levels (Effect = 0.009, SE = 0.006, 95% CI [0.001;0.023]; Figure 1B) and were not attenuated after adjustment for depression ratings (Effect = 0.010, SE = 0.006, 95% CI [0.001;0.026]). The gene discussed is APOE; the disease is major depressive disorder.