For instance, Tetraspanin1 stimulates FAM110A’s enhanced expression to encourage the growth and spread of pancreatic cancer (PAAD) cells (Huang et al., 2022); overexpression of FAM110B can inhibit Wnt/β-catenin signaling and thus inhibit the malignant biological activity of non-small cell lung cancer (NSCLC) cells (Xie et al., 2020); FAM110C contributes to the growth and migration of glioma (GBM) with isocitrate dehydrogenase1 (IDH1) mutation (Ren et al., 2023). Here, FAM110A is linked to non-small cell lung carcinoma.