CYP11B2 and adrenal cortex carcinoma: Although our recent preliminary in vitro findings revealed that transient silencing of CYP11B2 expression in the HAC15 human adrenocortical carcinoma cell line did not significantly induce cellular apoptosis (83), we observed that CYP11B2 silencing activated stress response mechanisms, including autophagy and mitophagy, potentially facilitating cellular adaptation to CYP11B2 modulation through cellular recycling or initiating cellular death response (84).