STIM1 knockout in precursor osteoclasts attenuates Ca2+ oscillations induced by RANKL (43), and ORAI1 knockdown impairs bone mineral resorption and leads to osteoclast deficiency, indicating that SOCE is essential for the Ca2+ oscillation/NFATc1-dependent signaling complex induced by RANKL (53, 54). The gene discussed is TNFSF11; the disease is hyperinsulinemic hypoglycemia, familial, 4.