C3 and Stroke: Notably, analysis of 341 DE mRNA associated with stroke (259 upregulated, 82 downregulated) in the IR group (Supplementary Figure S2) revealed upregulation of genes like Ccl2, Cxcl1, C3, Serpine1, Adamts7, Csf3, Ptx3, MMP8, Lif, and Lcn2, and downregulation of Gdf10, Agtr2 and Shank3 (Figure 5C).