Recently, corynoxine B was found to directly bind with HMGB 1/2 near the C106 site, enhancing the interaction between Beclin-1 and HMGB 1/2, thereby inducing autophagy and promoting the clearance of α-synuclein in both Drosophila and mice PD transgenic models with overexpression of α-synuclein (Zhu et al., 2023). The gene discussed is SNCA; the disease is Parkinson disease.