Considering the advantages of exosomes, which could be modified with target-specific receptor ligands on the surface, to cross the blood–brain barrier and then be uptaken by autologous cells, corynoxine B was carried by the Fe65-engineered HT22 hippocampus neuron cell-derived exosomes and delivered to the APP-overexpressed neuron cells in the brain of AD mice, where corynoxine B blocked the interaction between Fe65 and APP and induced autophagy, thereby ameliorating cognitive decline and pathogenesis in AD mice (Iyaswamy et al., 2023). This evidence concerns the gene APP and Mental deterioration.