Chen et al. (2024) additionally, Qi-Zhi-Wei-Tong particles alleviate inflammatory responses in mice by changing the gut microbiota and bile acid metabolism to treat CAG. According to the KEGG enrichment analysis, the therapeutic effect of botanical drugs in the M3 subgroup may involve the NF-kappa B signalling pathway and the JAK-STAT signalling pathway. Buzzelli et al. (2019) reported that the cytokine IL-11 is specifically overexpressed in the stomach and can trigger spontaneous atrophic gastritis via the gp 130-JAK-STAT 3 signalling pathway. This evidence concerns the gene SOAT1 and chronic atrophic gastritis.