TP53 and neoplasm: It was found that curcumin exerted its antitumor effect by regulating various signaling pathways, including inhibiting tumor cell proliferation, invasion and migration and promoting apoptosis through down-regulating the expression of Bcl-2 family proteins, up-regulating the expression levels of p53 and Caspase-3, etc (Jagetia and Aggarwal, 2007; Zhai et al., 2020).