WNT3 and breast cancer: In GTEx (atrial appendage tissue), we obtained the WNT3 target, which had a similar promotional effect on the development of AF (OR = 1.06, 95% CI, 1.02–1.10, Pfdr = 0.035, PPH3+PPH4 = 0.98) and breast cancer (OR = 0.93, 95% CI, 0.90–0.97, Pfdr = 0.017, PPH3+PPH4 = 1.00) were consistent with the previous findings (Figure 4).