(Figure 4) WNT3 was associated with a risk of promoting the development of atrial fibrillation (OR = 1.20,95%CI, 1.07–1.35, Pfdr = 0.023, PPH3+PPH4 = 0.92), and was associated with a risk of protecting against breast cancer (OR = 0.79,95%CI, 0.70–0.89, Pfdr = 0.024, PPH3+PPH4 = 0.99), and XBP1 similarly had a promotional effect on the occurrence of atrial fibrillation (OR = 1.07,95%CI, 1.03–1.11, Pfdr = 0.005, PPH3+PPH4 = 0.90) and ER + breast cancer (OR = 1.07,95%CI, 1.03–1.11, Pfdr = 0.032, PPH3+PPH4 = 1.00). This evidence concerns the gene ESR1 and atrial fibrillation.