Since the immune cell infiltration of the TME from BM and paired MS might differ, the frequencies and the spatial distribution of CD3+CD8- T cells, CD3+CD8+ T cells, CD3+FoxP3+ regulatory T cells (Treg) and CD3-MUM1+ B cells/plasma cells, CD3+GrB+ T cells were analyzed in 38 paired BMB and MS samples. This evidence concerns the gene CD8A and myeloid sarcoma.