found that blockage of Calcyclin-Binding Protein (CacyBP) would inhibit the expression of C-X3-C motif chemokine ligand 1 (CX3CL1), a key chemotactic factor for the recruitment of monocyte-derived macrophages to the liver (74), and thus significantly reduce TAM infiltration and achieve synergies with anti-PD-1 treatment in HCC (75). The gene discussed is CACYBP; the disease is hepatocellular carcinoma.