STAT3 and hepatocellular carcinoma: identified a 500-μm-wide zone centered around the tumor border in patients with liver cancer through nanoscale resolution-SpaTial Enhanced Resolution Omics-sequencing (Stereo-seq), referred to as “the invasive zone,” where overexpression of CXCL6 could induce activation of the JAK–STAT3 pathway, which causes SAAs’ overexpression and leads to the recruitment of macrophages and M2-like polarization, resulting in the formation of a local immunosuppressive microenvironment and the promotion of HCC invasion and migration (61).