found that protein kinase C alpha (PKCα) phosphorylates zinc finger protein 64 (ZFP64) at S226 and promotes its nuclear translocation, thereby transcriptionally activating CSF1, which further induces the recruitment and M2-like polarization of macrophages, inducing immune escape and anti-PD-1 resistance in HCC (70). Here, PRKCA is linked to hepatocellular carcinoma.