revealed that the TME endowed M2-like TAMs with a high capability of glucose uptake and utilization, which enhanced the activity of the hexosamine biosynthetic pathway to enhance O-GlcNAcylation on cathepsin B (CTSB) in TAMs, leading to an elevated mature form of CTSB and its secretion in the TME, which in turn promote tumor metastasis and chemoresistance (94). Here, CTSB is linked to neoplasm.