SAMM50 and colorectal carcinoma: We also performed mIHC staining in cohort 2, This cohort comprised 72 CRC patients post-neoadjuvant therapy, with 11 patients exhibiting complete or near-complete pathological response (TRG0 or TRG1) classified as the Response group, and 61 patients with minimal or no response (TRG2 or TRG3) as the Non-Response group.