SOD1 and familial amyotrophic lateral sclerosis: Molybdenum: Ammonium tetrathiomolybdate (TTM) can remove copper ions from copper thiolate clusters (such as SOD1), and played a therapeutic role in a mouse model of familial amyotrophic lateral sclerosis (ALS) caused by the SOD1 mutation [23], decreasing spinal copper levels and reducing lipid peroxidation.