In contrast, sortilin-deficiency was not sufficient to attenuate the loss of dorsal root ganglion (DRG) neurons after sciatic nerve injury [38] and in response to experimental autoimmune encephalomyelitis or experimental stroke, similar neurodegenerative effects were observed in sortilin-deficient mice and wild-type littermates [39]. Here, SORT1 is linked to experimental autoimmune encephalomyelitis.