This study also revealed that miR-125 b is a downstream target of HOXA-AS2, that HOXA-AS2 downregulates miR-125 b, and that interactions between HOXA-AS2, miR-125 b, and Smad2 are important for HOXA-AS2's functional role in mediating bladder cancer cells' stemness, migration, and invasion [134]. The gene discussed is HOXA-AS2; the disease is urinary bladder cancer.