According to a variety of studies, MEG3 is involved in the regulation of chemoresistance, cell proliferation, invasion, and migration through the “sponging” of mRNAs or miRNAs, and its depletion is reported to enhance stem-cell-like properties in a variety of cell types, including germline stem cells, mesenchymal stem cells, and lung cancer cells. Here, MEG3 is linked to lung carcinoma.