TNFSF10 and cancer: Stress ligands such as MHC I chain-related proteins A and B [16,17], UL16-binging proteins [16,18], and Tumour Necrosis Factor (TNF) - related apoptosis-inducing ligand (TRAIL) – R1/R2 ligands [[18], [19], [20]] are expressed at higher levels by cancer cells compared to normal cells.