M1 macrophages secrete high levels of pro-inflammatory factors such as interleukins (e.g., IL-6, IL-12), IFN-γ, and chemokines, which help clear invading pathogens and tumor cells, address ROS (reactive oxygen species)-induced tissue injury, impede wound healing and tissue regeneration, and enhance adaptive immunity [[11], [12], [13]]. This evidence concerns the gene IL6 and neoplasm.