Correlation analysis showed that RPS had a negative correlation the infiltration levels of most immune-activated, anti-tumor functional cells (such as activated CD8 T cells, CD56 bright natural killer cells and central memory CD4 T cells) and immune-suppressive, pro-tumor functional cells (such as CD56 dim natural killer cells, immature dendritic cells and macrophages) (Fig. 6B, Supplementary Table S3). The gene discussed is CD4; the disease is neoplasm.