Furthermore, in this same APP/PS1 mouse model, metformin treatment rescued spatial memory, prevented neuronal cells death, increased adult hippocampal neurogenesis, inhibited the inflammatory response, reduced proinflammatory cytokine levels, restored the antioxidant status and increased the protein levels of both p-AMPK and insulin-degrading enzyme (IDE), altogether contributing to an improvement in cognitive impairment [20,21]. This evidence concerns the gene IDE and Cognitive impairment.