Han et al. (2018) identified nonsense mutations in HPV 16-, 58-, and 53-positive squamous vulvar cell carcinoma samples in previously described genes involved in growth, survival, proliferation, motility, cell morphology, DNA repair, and protein degradation (PIK3CA, BRCA2, and FBXW7) [167]. This evidence concerns the gene PIK3CA and vulvar squamous cell carcinoma.