TP53 and cancer: Enrichment pathway analysis revealed that these genes are associated with signaling pathways such as PI3K, WNT-catenin, and P53, among others, and that they have a direct impact on the main hallmarks of cancer, such as apoptosis inhibition, immortalization, evasion of the immune response, metabolic reprogramming, metastasis, and angiogenesis (Fig. 3).