These chromosomes harbor genes associated with cancer development and progression, such as MYC, KLF5, KLF12, FHIT, HIF1A, RB1, TP63, TP53, BRCA2, LPR1B, PIK3CA, RBL1, PTEN, AKT1, TERT, CCND1, RICTOR, NOTCH1, KRAS and MTOR. This evidence concerns the gene KLF5 and cancer.