These chromosomes harbor genes associated with cancer development and progression, such as MYC, KLF5, KLF12, FHIT, HIF1A, RB1, TP63, TP53, BRCA2, LPR1B, PIK3CA, RBL1, PTEN, AKT1, TERT, CCND1, RICTOR, NOTCH1, KRAS and MTOR. The gene discussed is NOTCH1; the disease is cancer.