Enrichment pathway analysis revealed that these genes are associated with signaling pathways such as PI3K, WNT-catenin, and P53, among others, and that they have a direct impact on the main hallmarks of cancer, such as apoptosis inhibition, immortalization, evasion of the immune response, metabolic reprogramming, metastasis, and angiogenesis (Fig. 3). This evidence concerns the gene PIK3CA and cancer.