These chromosomes harbor genes associated with cancer development and progression, such as MYC, KLF5, KLF12, FHIT, HIF1A, RB1, TP63, TP53, BRCA2, LPR1B, PIK3CA, RBL1, PTEN, AKT1, TERT, CCND1, RICTOR, NOTCH1, KRAS and MTOR. Here, PTEN is linked to cancer.