These chromosomes harbor genes associated with cancer development and progression, such as MYC, KLF5, KLF12, FHIT, HIF1A, RB1, TP63, TP53, BRCA2, LPR1B, PIK3CA, RBL1, PTEN, AKT1, TERT, CCND1, RICTOR, NOTCH1, KRAS and MTOR. This evidence concerns the gene PIK3CA and cancer.