The analysis revealed that AFP >400 ng/ml [P = 0.009, hazard ratio (HR) = 5.452 (4.025–7.895)], PIVKA-II >40 mAU/ml [P = 0.041, HR = 2.251 (1.123–4.542)], incomplete tumor capsule [P = 0.013, HR = 4.279 (4.124–5.403)], Edmondson-Steiner grade III–IV [P = 0.019, HR = 3.547 (1.963–4.254)], and I-O and MTT [P = 0.042, HR = 0.657 (0.352–0.821)] were identified as independent risk factors for recurrence. Here, AFP is linked to neoplasm.