Similarly, AFP >400 ng/ml [P = 0.012, HR = 2.125 (1.874–4.356)], incomplete tumor capsule [P = 0.032, HR = 3.387 (1.811–4.474)] and I-O and MTT [P = 0.037, HR = 0.851 (0.622–0.914)] were independent prognostic factors of overall survival after hepatectomy for HCC with PVTT (Tables 2, 3). The gene discussed is AFP; the disease is hepatocellular carcinoma.