Among the immune cells related to cigarettes smoked per day, CD33- HLA DR+ Absolute Count highly supported the colocalization analysis (PH4 = 0.814), while HLA DR on CD33dim HLA DR+ CD11b + (PH4 = 0.696) and HVEM on naive CD4+ T cell (PH4 = 0.532) moderately supported the colocalization analysis in relation to obesity (Supplementary Table S5). The gene discussed is CD4; the disease is Obesity.