MAPT and Cognitive impairment: By increasing the level of mitophagy, Aβ deposition can be reduced and the phagocytosis and anti-inflammatory effects of microglia can be modulated, which in turn attenuates cognitive deficits in APP/PS1 mice; mitophagy also inhibits the overphosphorylation of tau proteins and ameliorates the memory deficits in the genetically modified nematode Hidradenitis elegans cryptic rod nematode and APP/PS1 mice (Fang et al., 2019).