SIRT1 and Cognitive impairment: However, after intervention with an inhibitor of SIRT1, it was found that the above results were inextricably linked to the upregulation of SIRT1, i.e., BDMC could alleviate cognitive deficits in APP/PS1 mice by upregulating SIRT1 to achieve an anti-oxidative stress effect (Xu et al., 2020).