Today, ApoE has been associated with various diseases, including Alzheimer’s disease (AD), infectious diseases such as Covid-19, cancer, metabolic syndrome, glomerulopathy, fertility, and longevity (Mahley, 1988; Martínez-Martínez et al., 2020; Saito et al., 2020; Yu et al., 2022; Zhang et al., 2022) (Figure 1). This evidence concerns the gene APOE and metabolic syndrome.