APOE and Alzheimer disease: Liu et al. (2021) further demonstrated the mechanism of APOE3-V236E mutation against AD included downregulation of ApoE4 self-aggregation, enhancement of ApoE lipidation, and decreased amyloid deposition toxicity, which together promoted healthy brain aging. APOE3-V236E mutation was named as APOE3-Jacksonville variant based on the city where the study was primarily conducted.