IL1B and myeloid sarcoma: Notably, interleukin (IL)-1β, induces synaptic hyperexcitability and promotes excitotoxic neuronal damage by exacerbating glutamate-mediated neuronal excitability and reducing GABA-mediated inhibition in MS chimeric ex-vivo models (Rossi et al., 2012a,b; Mandolesi et al., 2015).