Patients with JDM who present with anti-TIF-1γ antibodies and associated autoantibodies exhibit less muscle weakness, less frequent skin ulcers, and lower anti-TIF-1γ autoantibody titers (29) perhaps because, in this subgroup of patients, the titer of anti-TIF-1γ autoantibodies appears to decrease due to other autoantibodies targeting antigens that form complexes with TIF-1γ (28). The gene discussed is TRIM33; the disease is Skin ulcer.